Macular Focus® + Multivitamin

Understanding the Science Behind Macular Focus®

AREDS and AREDS 2: The Foundation of Eye Health
The Age-Related Eye Disease Study (AREDS) and its follow-up, AREDS 2, were landmark clinical trials sponsored by the National Eye Institute (NEI) to investigate age-related macular degeneration (AMD) and cataracts, and the role of nutritional supplements in slowing disease progression.

• AREDS (1992–2001) included 3,640 participants aged 55–80 over 6.3 years. It showed that a high-dose formulation of antioxidants (vitamins C and E, beta-carotene) and zinc reduced the risk of advanced AMD by ~25% in individuals with intermediate AMD or advanced AMD in one eye. No significant effects were found for cataracts.
  
  
• AREDS 2 (2006–2011) improved the original formula by replacing beta-carotene with lutein and zeaxanthin, reducing zinc, and adding omega-3 fatty acids. The study confirmed that lutein and zeaxanthin maintained AMD protection and were safer for former smokers. Omega-3s did not provide additional benefits. Today, the AREDS 2 formulation is recommended for those with intermediate or advanced AMD.

Macular Focus® builds on this clinically proven foundation, delivering targeted eye protection through a next-generation AREDS 2–based formula.

Why Taurine Was Not Included

Recent research has shown that taurine can fuel the growth of leukemia cells by promoting glucose metabolism in cancerous tissues. To maximize safety, Nutrient Revolution removed taurine from both Macular Focus® and Macular Focus® Plus Multivitamin.

Macu-LZ™: Advanced Carotenoid Protection

Macular Focus® features Macu-LZ™, a plant-based, non-GMO, vegetarian, gluten-free, Kosher and Halal-certified blend of lutein, RR-zeaxanthin, and RS (meso)-zeaxanthin. These macular carotenoids support eye, brain, and skin health while protecting against harmful blue light from digital screens and LED lighting. Clinical studies, including AREDS 2, demonstrate that lutein and zeaxanthin supplementation can increase macular pigment density, improve visual function, and slow AMD progression.

Key Ingredients and Why They Matter

• Trans-Resveratrol (60 mg): Protects retinal cells, supports mitochondrial health, and reduces anti-VEGF injections and macular fibrosis in wet AMD.
  
  
• Zinc (25 mg as Zinc Gluconate): Clinically proven to slow AMD progression at a safe and highly absorbable dose.
  
  
• Coenzyme Q10 (100 mg): Supports retinal cell mitochondrial health and reduces oxidative stress.
  
  
• Astaxanthin (6 mg): Powerful antioxidant that protects retinal cells, supports retinal function, and reduces inflammation.
  
  
• Black Currant (50 mg): Supports ocular blood flow, dark adaptation, and resilience against blue light and AMD.
  
  
• Saffron (20 mg): Protects retinal cells from oxidative stress, supports visual function, and helps stabilize macular structure.
  
  
• Bilberry (25% Anthocyanidins): Enhances retinal antioxidant defense and supports retinal health.
  
  
• Lycopene: Reduces oxidative stress and inflammation, protecting retinal pigment epithelial cells in dry and wet AMD.
  
  
• Maqui Berry (60 mg): Protects retinal cells, improves tear production, and defends against blue light–induced damage.

Why Macular Focus® Matters

Macular Focus® is a scientifically formulated approach tolong-term visual preservation. By combining the AREDS 2 foundation with advanced antioxidants, carotenoids, and protective botanicals, it helps maintain retinal health, supports blue light protection, and addresses the key drivers of AMD progression. Every ingredient was chosen based on clinical evidence, bioavailability, and safety, providing a next-generation solution for today’s digital lifestyles.

Is Macular Focus plus Multivitamin® a prescription medication?

No, Macular Focus® is not a prescription medication. It is available as a dietary supplement and can be purchased without a prescription. However, it's essential to consult with a licensed healthcare professional before starting any new supplement, especially if you have underlying health conditions or are taking medications.  Do not use this product if you are pregnant or breastfeeding, have a blood clotting disorder or are taking blood-thinning (anticoagulant) medication.  Discontinue use at least 2 weeks prior to undergoing surgery.  Not recommended for persons under the age of 18.

How should I take Macular Focus®?

As a dietary supplement for immune support, the suggested use is 2 capsules in the morning and 2 capsules in the evening with 10-12 fl oz. of water. However, it's crucial to follow the dosage instructions and warnings provided on the product label or as directed by your licensed healthcare professional. Do not exceed the recommended dosage.

†These statements have not been evaluated by the Food and Drug Administration.  This product is not intended to diagnose, treat, cure or prevent any disease.

References

1. Age-Related Eye Disease Study Research Group. (2001). A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Archives of Ophthalmology, 119(10), 1417–1436. https://doi.org/10.1001/archopht.119.10.1417
   
   
2. Age-Related Eye Disease Study 2 Research Group. (2013). Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: The Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. JAMA, 309(19), 2005–2015. https://doi.org/10.1001/jama.2013.4997
   
   
3. Sharma, S., Rodems, B.J., Baker, C.D. et al. (2025). Taurine from tumour niche drives glycolysis to promote leukaemogenesis. Nature. https://doi.org/10.1038/s41586-025-09018-7
   
   
4. Richer, S., et al. (2021). Double-masked, placebo-controlled, randomized trial of lutein and zeaxanthin supplementation in patients with early age-related macular degeneration. Clinical Ophthalmology, 15, 1533–1545. https://doi.org/10.2147/OPTH.S307092
   
   
5. Renzi-Hammond, L. M., et al. (2020). A randomized trial on the effects of blue light–blocking filters on visual performance and macular pigment. PLOS ONE, 15(6), e0234504. https://doi.org/10.1371/journal.pone.0234504
   
   
6. Datseris I, et al. (2025). Resveratrol supplementation in wet AMD: association with fewer intravitreal injections and reduced macular fibrosis. Clin Ophthalmol, 19, 217–225. https://doi.org/10.2147/OPTH.S494595
   
   
7. Bosch-Morell, F., et al. (2020). Medicinal plants and natural products as neuroprotective agents in age-related macular degeneration. Neural Regeneration Research, 15(12), 2207–2216. https://doi.org/10.4103/1673-5374.284978
8. Cirilli, I., et al. (2021). Role of coenzyme Q10 in health and disease: An update on the last 10 years (2010–2020). Antioxidants, 10(8), 1325. https://doi.org/10.3390/antiox10081325
   
   
9. Giannaccare, G., et al. (2020). Clinical applications of astaxanthin in the treatment of ocular diseases: Emerging insights. Marine Drugs, 18(5), 239. https://doi.org/10.3390/md18050239
   
   
10. Shin, C. Y., et al. (2022). Protective effect of Ribes nigrum extract against blue light-induced retinal degeneration in vitro and in vivo. Antioxidants, 11(5), 832. https://doi.org/10.3390/antiox11050832
    
    
11. Bosch-Morell, F., et al. (2020). Saffron and visual function in early-stage AMD. Neural Regeneration Research, 15(12), 2207–2216. https://doi.org/10.4103/1673-5374.284978
    
    
12. Fursova, A. Z., et al. (2005). Dietary supplementation with bilberry extract prevents macular degeneration and cataracts in senescence-accelerated OXYS rats. Advances in Gerontology, 16, 76–79. https://doi.org/10.1134/1607568005010160
    
    
13. Nidhi, R., et al. (2011). Serum antioxidant levels in age-related macular degeneration. Indian Journal of Ophthalmology, 59(2), 115–118.