Macular Focus®

AREDS and AREDS 2: Eye Health You Can Trust

The Age-Related Eye Disease Study (AREDS) and AREDS 2 are landmark NEI-sponsored trials demonstrating that targeted nutritional supplements can reduce the risk and progression of age-related macular degeneration (AMD).

• AREDS (1992–2001): High-dose antioxidants (vitamins C and E, beta-carotene) plus zinc reduced the risk of advanced AMD by ~25% in individuals with intermediate or advanced AMD in one eye.
• AREDS 2 (2006–2011): Improved the original formulation by replacing beta-carotene with lutein and zeaxanthin and reducing zinc. This maintained AMD protection, safer for former smokers, while omega-3 fatty acids did not show additional benefit.

Macular Focus® Plus Multivitamin builds on this evidence-based foundation, combining retinal protection with full-spectrum daily nutrition in a single, convenient formula.

Why Taurine Was Not Included

Research indicates that taurine can promote growth in certain leukemia cells, so it was removed from both Macular Focus® and Macular Focus® Plus Multivitamin to ensure safety.

Macu-LZ™: Advanced Eye Protection

This formula includes Macu-LZ™, a blend of lutein, RR-zeaxanthin, and RS (meso)-zeaxanthin, clinically proven to support macular health, increase macular pigment density, and protect against harmful blue light from screens and modern lighting.

Key Ingredients and Benefits

• Trans-Resveratrol (60 mg): Protects retinal cells, supports mitochondrial health, and reduces macular fibrosis in wet AMD.
• Zinc (25 mg as Zinc Gluconate): Clinically proven to slow AMD progression while minimizing side effects.
• Coenzyme Q10 (100 mg): Supports mitochondrial function in retinal pigment epithelial cells and reduces oxidative stress.
• Astaxanthin (6 mg): A potent antioxidant that protects retinal cells, reduces inflammation, and supports macular function.
• Black Currant (50 mg): Improves ocular blood flow, dark adaptation, and resilience against blue light–related stress.
• Saffron (20 mg): Supports retinal health, visual function, and macular stability.
• Bilberry (25% Anthocyanidins): Protects against oxidative stress and inflammation in retinal cells.
• Lycopene: Supports both dry and wet AMD by reducing oxidative stress and inflammation.
• Maqui Berry (60 mg): Protects against blue light–induced retinal damage and supports dry eye relief.
• Full-Spectrum Multivitamins and Minerals: Provides essential nutrients for overall health, supporting cardiovascular, immune, and neurological function.

Why Choose Macular Focus® Plus Multivitamin?

This all-in-one solution simplifies your daily routine by combining advanced eye protection with complete daily nutrition. By addressing both visual and systemic health, Macular Focus® Plus Multivitamin provides a convenient, science-backed approach to supporting healthy aging, retinal preservation, and overall wellness—all without needing multiple supplements.

Is Macular Focus plus Multivitamin® a prescription medication?

No, Macular Focus plus Multivitamin® is not a prescription medication. It is available as a dietary supplement and can be purchased without a prescription. However, it's essential to consult with a licensed healthcare professional before starting any new supplement, especially if you have underlying health conditions or are taking medications.  Do not use this product if you are pregnant or breastfeeding, have a blood clotting disorder or are taking blood-thinning (anticoagulant) medication.  Discontinue use at least 2 weeks prior to undergoing surgery.  Not recommended for persons under the age of 18.

How should I take Macular Focus plus Multivitamin®?

As a dietary supplement for immune support, the suggested use is 2 capsules in the morning and 2 capsules in the evening with 10-12 fl oz. of water. However, it's crucial to follow the dosage instructions and warnings provided on the product label or as directed by your licensed healthcare professional. Do not exceed the recommended dosage.

†These statements have not been evaluated by the Food and Drug Administration.  This product is not intended to diagnose, treat, cure or prevent any disease.

References

1. Age-Related Eye Disease Study Research Group. (2001). A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Archives of Ophthalmology, 119(10), 1417–1436. https://doi.org/10.1001/archopht.119.10.1417
2. Age-Related Eye Disease Study 2 Research Group. (2013). Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: The Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. JAMA, 309(19), 2005–2015. https://doi.org/10.1001/jama.2013.4997
3. Sharma, S., Rodems, B.J., Baker, C.D. et al. (2025). Taurine from tumour niche drives glycolysis to promote leukaemogenesis. Nature. https://doi.org/10.1038/s41586-025-09018-7
4. Richer, S., et al. (2021). Double-masked, placebo-controlled, randomized trial of lutein and zeaxanthin supplementation in patients with early age-related macular degeneration. Clinical Ophthalmology, 15, 1533–1545. https://doi.org/10.2147/OPTH.S307092
5. Renzi-Hammond, L. M., et al. (2020). A randomized trial on the effects of blue light–blocking filters on visual performance and macular pigment. PLOS ONE, 15(6), e0234504. https://doi.org/10.1371/journal.pone.0234504
6. Datseris I, et al. (2025). Resveratrol supplementation in wet AMD: association with fewer intravitreal injections and reduced macular fibrosis. Clin Ophthalmol, 19, 217–225. https://doi.org/10.2147/OPTH.S494595
7. Bosch-Morell, F., et al. (2020). Medicinal plants and natural products as neuroprotective agents in age-related macular degeneration. Neural Regeneration Research, 15(12), 2207–2216. https://doi.org/10.4103/1673-5374.284978
8. Cirilli, I., et al. (2021). Role of coenzyme Q10 in health and disease: An update on the last 10 years (2010–2020). Antioxidants, 10(8), 1325. https://doi.org/10.3390/antiox10081325
9. Giannaccare, G., et al. (2020). Clinical applications of astaxanthin in the treatment of ocular diseases: Emerging insights. Marine Drugs, 18(5), 239. https://doi.org/10.3390/md18050239
10. Shin, C. Y., et al. (2022). Protective effect of Ribes nigrum extract against blue light-induced retinal degeneration in vitro and in vivo. Antioxidants, 11(5), 832. Protective Effect of Ribes nigrum Extract against Blue Light-Induced Retinal Degeneration In Vitro and In Vivo